Evaluation of the effects of donepezil, memantine and α-lipoic acid combined administration in amnesia rats on impaired cognitive functions in terms of behavioural, apoptotic, cholinergic and glutamatergic systems

Objective: The aim of the study was to evaluate possible protective effects alpha-lipoic acid (α-LA), donepezil and memantine combined therapy in scopolamine-induced amnesia rat model. 
 effect donepezil, (α-LA) Methods: In this study, used treatment on behavioural parameters evaluated using Y-maze new object recognition (NOR) test. addition, muscarinic acetylcholine receptor subtype M1, N-methyl-D-aspartate NR2B subunit, brain-derived neurotrophic factor (BDNF) mitochondrial apoptosis-related proteins [B-cell lymphoma-2 (Bcl-2) / Bcl-2 associated X (Bax) ratio, caspase (casp) -3, -9] expression levels were western blot method frontal cortex hippocampus regions. Results: main findings demonstrated that rats, cognitive dysfunction determined by both NOR test reversed with memantine, α-LA. According immunoblotting results brain regions, decreased BDNF, Bax ratio increased NR2B, casp-3 -9 found be almost control values treatment. Conclusion: Consistent literature, our suggest positive contribution α-LA which is routine neurodegenerative diseases, may a option future.
 NORT bcl-2/bax caspase-3 caspase-9 due scopolamine regions improved α-LA, therapy. other literature future its drugs diseases.